Building a Better San Diego for Future Generations
This is the TL Foundation: A testament to the enduring spirit of San Diego’s entrepreneurial leadership and commitment to community. We aren’t just supporting projects; we are investing in the future, the ideas, and the people that will shape our tomorrow. We are building the best inclusive innovation ecosystem on the planet.
The individuals behind the TL Fund care deeply about San Diego. They also happen to be some of the most established investors and leaders in San Diego, with extensive backgrounds across both tech and life sciences.
Unlike any other fund, TL operates without a management fee, and without any single person getting a carry. All returns go right back into the foundation’s fund, so that it grows exponentially. It is designed to give back to future generations of San Diegans in perpetuity.
Connect announced the first TL Fund investments into four local companies in September 2024. Read the press release.
For more information about the TL Foundation, contact CEO, Mike Krenn.
Condor is a vertical SaaS product for biopharma, providing a financial system of record that helps biopharma CFOs understand, control, and report their biggest expense in an SEC-compliant manner. Financial visibility, cost-efficiency, and SEC audit compliance are paramount in this industry given an inflationary environment and increased audit scrutiny on the industry. The Condor platform roadmap includes predictive forecasting, generative budgeting, scenario planning and collaboration connectivity to help bring more life-saving drugs to market faster and more cost-effectively.
Looq is dedicated to bringing AI to build a better built world. Climate change and increased societal pressures put our outdated infrastructure at risk, driving the need to inspect, repair and maintain it faster than ever before. Looq automates the creation of 3D Digital Twins- capturing the complex physical world and creating detailed 3D models. The company’s software vision technology cuts field survey times by over 100x, amplifies data value using its proprietary AI, and powers collaboration across global engineering teams.
Papillon Therapeutics is advancing gene therapy treatments for life threatening conditions including Friedreich’s ataxia, Danon disease, and Alzheimer’s disease. The company specializes in developing gene modified hematopoietic stem and progenitor cell (HSPC) therapies, leveraging the natural capacity of these unique cells to safely deliver a gene therapy throughout the body. Papillion’s clinical stage program for treatment of Cystinosis reported positive data in a Phase 1/2 clinical trial and is being advanced by Novartis. Non-dilutive funding has been awarded to advance research around Cystinosis, Friedreich’s ataxia, and Danon disease programs.
Resolute Science is a preclinical biotechnology company developing cancer therapeutics for aggressive and hard-to-treat solid tumors. These cancers are characterized by an abundance of tumor associated macrophages (TAMs) that support tumor growth. Instead of fighting TAMs, Resolute uses their natural cellular machinery to process and deliver cancer-killing agents directly into adjacent cancer cells. Based on Resolute’s modular technology platform, the company’s lead therapeutic MAC-TAC (Macrophage Targeted Conjugates demonstrates powerful anti-cancer efficacy in tumor models. The flexible design has the potential to deliver superior safety and efficacy to those cancer patients who have run out of treatment options.
San Diego’s innovation economy is more than a sector. It’s foundational to every region’s future on the global stage. There will be winners and losers. We are positioning San Diego to not only thrive, but to be a better community as we grow. We aspire to create economic opportunity for families across the entirety of our megaregion.
The TL Fund is a BIG idea.
We’ve already helped San Diego grow from a $1B venture market to one that is now $5B annually, the fifth largest venture investment market in the country. TL is admittedly a small investor as a “fund.” But our focus is distinct. Others simply seek “bigger.” We will fill gaps, do the work, engage leaders, and focus our efforts to make San Diego “better.”
We are building the best inclusive innovation ecosystem on the planet.
A relatively small group of folks (Conrad Prebys, Irwin & Joan, The Radys, Malin, and others) helped make this city what it is. They inspire us. We want to continue their legacy, and make San Diego better for future generations.
Before those philanthropists, there was Kate Sessions. When Kate came to town, San Diego was essentially a desert. She discovered trees that would thrive here, and changed our city forever.
The metaphor is simple and aspirational. Kate started with one tree. She inspired others. Together, they transformed San Diego forever.
We can do the same. Our economy is foundational for the region. While the fund will enable thoughtful investment for generations, the “Tree Lady Club” can be even bigger than the fund. We are gathering leaders – leaders who care about the future of our region. Working together, we can help create the change we want for our region’s economic future. The goal is simple: to create the best innovation ecosystem on the planet.
From the company’s perspective – not much at all. Companies will receive a traditional, founder-friendly investment. From the fund’s perspective – it is entirely different. No one gets rich but San Diego. The investors will not get their money back, their investment is 100% philanthropic. Similarly, the managers of the fund will get neither a carry (typically 20% of the returns), nor a management fee (typically 2% of assets under management. Instead, all returns will go right back into the Foundation to be redistributed back into the ecosystem.
Our goal is to build a large evergreen fund that continually gives back to San Diego in perpetuity. Hopefully a $15M fund becomes $30M, which grows to $100M years from now. Those dollars will get invested back into the startup community, creating high-quality jobs across the region. We believe a strong, diverse base of innovation companies creates a strong macro economy. Our intention is to be a tier one global innovation hub. Not necessarily the biggest – but the best inclusive innovation ecosystem on the planet.
No, San Diego is the first. This is for San Diego by San Diegans – people who are passionate about the future of our region, and making it better for generations to come. San Diego is awesome, and we intend to make it even better.
There isn’t an 8-week cohort approach. Working with Connect, we are there to help your company scale well beyond the 8 weeks, for many years ahead. We can access different industry experts and advisors over the lifecycle of the company, depending on the needs and stage of the company. Connect is uniquely successful with a long history of helping local companies raise venture funding, further enhancing the trajectory of companies selected.
Admittedly, the early years are focused on getting positive returns, and growing the size of the fund. Once we get to sufficient size, the board has the ability to make grants and other investments to help the broader mission of creating economic opportunity across the region. The bigger the fund, the greater the impact the Foundation can make.
Anyone who believes that a strong innovation economy is important to the future prosperity of San Diego and all families across our megaregion. If you’re interested in learning more, we’d love to talk to you. We are extremely grateful to our initial backers, Buzz Woolley and Malin Burnham.
Nonprofits designed to support economic opportunity are strangely hard to build. We’re just not high on philanthropic radars. Yet what we do, building a strong diverse economy, is foundational to the region’s future.
Mike Krenn, who is CEO of Connect, is also CEO of the Fund, with zero upside. Mike is the former founder of Tech Coast Angels (now NuFund) and has helped more than 100 companies raise venture capital, well in excess of $800M.
Dave Titus, a former venture capitalist who has a long history in San Diego as the founder of Windward Ventures, will oversee the application and investment process. A separate investment committee will approve all investments.
For this cycle, companies must apply through the Connect Cool Companies program. The application and more info on Cool Companies can be found on the Connect website at connect.org. There are typically thirty Cool Companies every year, of which five will be selected for investment.
The first wave of investments were made in September 2024. Check out the press release!
Connect was founded by amazing individuals – people like Buzz Woolley, Irwin Jacobs, David Hale, and Mary Walshok – who paved the way for San Diego to have an amazing innovation ecosystem. At the same time, San Diego has benefited from the generous philanthropy of a handful of individuals, people like Buzz, Malin Burnham, Irwin Jacobs, Ernest Rady, Conrad Prebys, David Hale and Denny Sanford. These people largely created the San Diego we love. We hope to inspire the next generation of leaders in their likeness.
Stay informed with the TL Foundation by subscribing to Connect’s Newsletter and following on social media. Start the conversation about donating today!
Connect is a mission-driven 501c3 non-profit organization
