Cool Companies
The fastest, most-exciting startups in Southern California
Applications Are Officially Closed
Cool Companies is Connect’s annual capital program designed to match San Diego’s top-performing technology and life sciences startups ready to raise Series A — with quality venture capital.
Since 2015, Cool Co’s have raised over $850M+
… And counting!
( just in Institutional Series A )
Top Three Reasons to Apply
- Exposure to Connect’s extensive network of quality venture capital
- Receive the help you need to grow + scale your business
- Make connections with highly-accomplished individuals at premier San Diego innovation events
Class of 2022 Cool Companies
Have questions?
Learn more about the Cool Companies program with these Frequently Asked Questions.
Or…
If you feel your company is ready for venture capital, but would like to discuss your business with an advisor before applying, be sure to check out our Springboard program. (companies will be helped on a first-come, first-serve basis)
Thank you to the 2023 Cool Companies Program Sponsors
Connecting Tech & LifeSci Startups w/ Capital
Meet the 2022 Cool Companies
- All
- Tech
- LifeSci
Abilita Bio
Abilita Bio is a biotechnology company focused on enabling discovery and development of drugs targeting membrane proteins, including G Protein Coupled Receptors (GPCRs) and ion channels.
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Advanced Image Robotics
AIR is building remote video capture, storage, and distribution solutions for the Digital Age. The AIR platform marries robotics, machine-intelligence, and an intuitive interface to simplify high-end camera control and reduce production costs.
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Aeromutable
Aeromutable has developed a non-intrusive add-on system that, through the use of air injection, significantly improves aerodynamic performance and reduces fuel consumption and carbon emissions of trucks.
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Applied Surgical Robotics
Applied Surgical Robotics has developed a Robotic Surgical Assistant that creates stable and predictable surgical environments, eliminating the variation inherent with manual organ stabilization. Our proprietary platform (hardware + SaaS) is purposely designed to compliment and seamlessly integrate with other robotic devices, while using the existing instruments and end effectors that surgeons prefer.
Read More >
Benchmark Labs
Benchmark Labs combines grid level weather data with site-based IoT sensors, and uses their proprietary AI software to provide precise asset-located weather forecasting to optimize renewable energy generation & water allocation, reduce spatial basis risk and maximize financial benefits.
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BetFully
BetFully is a new Universal Gambling Rewards program for the rapidly growing online sports betting industry. Millions of sports bettors participate on a regular basis and BetFully gives them up to 10% cashback on their deposits and betting whether they win or lose. Users also have access to premium sports data for free, a $1,200 […]
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CARI Health
CARI Health is developing the next generation of Remote Medication Monitors that will allow clinicians to prescribe medications and receive real-time reporting on medication levels. CARI’s small, wireless sensors are worn on the patient’s skin and continuously monitor medication levels, sending alerts when necessary. With a CARI Remote Medication Monitor clinicians can provide precision care […]
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ChargeNet Stations
ChargeNet Stations helps Quick Serve Restaurant (QSR) owners integrate, and extend, food sales into the parking lot via EV Fast Charging and renewable power infrastructure. Our ChargeOpt hardware-agnostic SaaS platform optimizes EV chargers and renewable energy turning parking lots into profit centers.
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Commsafe AI
CommSafe AI is a SaaS company that specializes in conflict and violence prevention. The CommSafe AI technology flags and labels employee communication containing triggers of toxic communication. Once a communication is triggered, the technology automatically sends an alert to HR, making them aware of the otherwise hidden liability, and provides them with next step recommendations. […]
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Cooler Heads
Cooler Heads has developed a cold cap, FDA approved, to help cancer patients keep their hair while undergoing chemotherapy
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CRISPR-QC
CRISPR QC will become the standard by which CRISPR based therapeutics and other applications are measured, audited and guaranteed for high quality, effective outcomes.
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Defined Bioscience
Defined Bioscience is a San Diego-based startup focused on making robust, fully-defined, high-quality ingredients for stem cell culture, with applications in the life science, biopharmaceutical, and cultured meat sectors.
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DockWorks
DockWorks’ mission is the mobilization and modernization of the marine services industry. Our vision is a full-service operations platform that enables marine professionals to manage, optimize and scale their business.
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EndoCyclic Therapeutics
EndoCyclic Therapeutics is a biopharmaceutical company engaged in the development of the first non-hormone therapeutic for endometriosis.
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Endure Biotherapeutics
Endure Biotherapeutics is developing engineered engraftable live biotherapeutics for gastrointestinal diseases by genetically engineering man’s native bacteria to express therapeutic compounds (such as anti-inflammatory cytokines).
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f5 Therapeutics
f5 Therapeutics harnesses the power of protein degradation to transform human health.
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FAScinate Therapeutics
FAScinate Therapeutics are developing novel drugs for CNS disease area. Our KM-819 is a First-in-Class, Disease modifying drug candidate for neurodegenerative diseases such as Parkinson’s disease and Multiple System Atrophy to stop or slow down the disease progression.
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Fenix Space
Fenix Space is developing the next-generation air-launch platform to deliver payload to low earth orbit at a fraction of the cost of current solutions.
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Fluid Power AI
Fluid Power AI offers Reliability as a Service for the equipment that powers a $7T economy. Our IoT reliability and maintenance solution for ANY hydraulic system keeps an organization’s most valuable assets earning. Reliability as a Service is a hardware-enabled SaaS business model. Fluid Power AI provides out of the box, plug-n-play, real-time full system […]
Read More >
GoShare
We use technology to improve last-mile delivery and moving experiences for our customers. Our mission is to organize the world’s trucks to make them more accessible and useful. Our vision is to create the largest network of trucks in the world. More than 90,000 customers and 12,000 Delivery Professionals trust GoShare to deliver. 2019, 2020, […]
Read More >
HAI Solutions
HAI Solutions has developed a unique portfolio of medical devices addressing the growing plague of contamination within the operating room, emergency room and intensive care units. We are focused on launching both the MDD-Multiport Delivery Device and IVS-Intravenous Sterilizer. While these products are two separate devices, they are complimentary and tackle the arduous clinical workflows […]
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Hillhurst Biopharmaceuticals
Hillhurst Biopharmaceuticals, Inc. (“Hillhurst”), a clinical-stage biopharmaceutical company focused on developing oral therapies enabling the therapeutic use of low dose carbon monoxide (CO).
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Intrepid Automation
Intrepid Automation develops custom industrial 3D print systems to produce plastic, elastomeric, and cast metal parts.
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Ivy Energy
Ivy Energy is opening up the most cost-effective deployment model for residential solar by fixing the split incentive issue for MDUs and more.
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La Jolla NanoMedical
La Jolla NanoMedical is a platform product for non surgical treatment of skin cancer and certain other cancers.
Read More >
MediPrint Ophthalmics
MediPrint Ophthalmics (FKA Leo Lens Pharma) is an emerging San Diego-based clinical stage eye care pharmaceutical company focused on enhancing vision for life by developing and commercializing a proprietary ocular drug delivery portfolio. There are over 40 million soft contact lens wearers in the United States alone and most of them will develop some eye […]
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Meetlete
Meetlete’s mission is to create personal connections between fans and athletes. Our app gives fans the ability to experiences a one on one meet and greet with their favorite athletes.
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MuReva Phototherapy
MuReva Phototherapy has developed a novel device using photomodulation to treat oral mucositis, a very painful side effect of radiation therapy in cancer patients
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OmniSync
OmniSync is a VC and US Air Force-backed, single sign-on software to find and fund innovation. We use AL/NLP-powered context-matching algorithms to create non-obvious connections between public/private innovators, scouts, and funders. Our flagship product, TurboSBIR helps startups connect with $4B in Federal innovation funds.
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OrPro Therapeutics
OrPro Therapeutics, Inc. (San Diego, CA) is developing a therapeutic platform based on thioredoxin, a human protein disulfide-reducing enzyme with unique mucus-normalizing, anti-inflammatory and anti-infective properties.
Read More >
PatientPartner
PatientPartner is creating the home for healthcare. We are a platform that provides access to information and support by connecting patients to a community of top-tier physicians and other patients going through similar health concerns, surgeries, or treatments.
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ProciseDx
ProciseDx provides point-of-care testing that delivers precise, high-quality results—empowering physicians and patients
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Radicle Science
Radicle Science reimagines the traditional pharmaceutical and academic research model to deliver rigorous health outcome data at a fraction of the time and cost. Our virtual, direct-to-consumer clinical trials offer the first ever path to natural product validation.
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Shadowbox
Shadowbox is a ground-breaking, patented, secure, no-code SAAS integration platform that connects web applications without the need for APIs. Our first product was launched in late 2018 targeting interoperability in healthcare, connecting Electronic Health Records (“EHRs”) with Ancillary Healthcare Service Systems (i.e., Diagnostic Labs, Treatment Centers, Durable Medical Equipment, Hospice Care, and so on).
Read More >
Styx Biotechnologies
At Styx, we are reprogramming immune cells to generate more robust and enduring immune responses. Our pioneering approach has remarkably improved the effectiveness of existing, fragile vaccines, and developing novel vaccine-based therapies against deadly diseases like COVID-19, pancreatic cancer, among others.
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Tag-N-Trac
Our CMaaS (Continuous Monitoring as a Service) Platform combined with our discreet Smart Sense™label technology provides the fabric for thorough supply chain visibility and real-time analytics. Our solution uniquely combines the initial process of serialization/aggregation of inventories, condition monitoring, and real-time alerts to keep track of product integrity during the chain of custody.
Read More >
The Good Face Project
The Good Face Project is an AI-Powered SaaS platform for R&D and Innovation in the Cosmetics and Personal Care Industry. We have created the LARGEST science-backed and AI-powered cosmetic ingredients ontology, with over 100,000 individual cosmetic ingredients graded across 15 dimensions of safety and efficacy.
Read More >
Trabus Technologies
TRABUS provides professional support services to the U.S. government and specializes in the development of technical solutions across five major portfolios: Wireless Technologies, Artificial Intelligence & Data Science, Maritime Transportation, Environmental Informatics, and Cybersecurity.
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Trestle Biotherapeutics
Trestle Biotherapeutics is a pre-clinical stage company developing bioengineered therapies for patients living with end stage renal disease. Once implanted, these bioengineered stem cell-derived tissues will get patients off dialysis, delay their need for transplantation, and one day become replacement organs.
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Verity Packaging
Verity offers truly sustainable packaging solutions to brands and businesses committed to combating the plastic crisis. We are on a mission to raise the standards in both packaging options and services to our clients.
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Vizer
Vizer is a fitness app that incorporates user rewards and social impact through meal donation. In 2020, they were awarded $500K from Alliance Healthcare Foundation. In 2020, they graduated the Connect Springboard program.
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XILO
XILO helps insurance agencies compete against rising digital competition with an easy to use, fully customizable software platform they can use to engage with their customers, provide instant insurance quotes and automate sales workflows. As part of the next generation of agency technology, XILO is aiming to disrupt old muti-billion dollar incumbents who control the […]
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Yur
The #1 fitness tracker for AR / VR / Gaming and #1 health and wellness bot for Discord. Community is the modern-day moat for companies. YUR helps champion online communities in an engaging way by blending IRL & URL activities.
Read More >Meet the 2021 Cool Companies
- All
- Tech
- LifeSci
1859
1859 is creating a pico-scale HTS platform (pico-HTS) that enables us to test millions of potential medicines in a single day. Our technology also allows us to rapidly explore chemical space and construct novel chemical diversity “on-demand”. This allows us to discover more medicines and get them to the clinic faster. At scale our technology […]
Read More >
Abterra Bio
Abterra Bio uses machine learning to mine the human immune system to discover novel antibody therapeutics. Patients mount lasting antibody responses to infectious diseases and cancer. Our platform uses next-generation sequencing and mass spectrometry data to comprehensively map this antibody response, rapidly identifying better therapeutic antibodies. We’ve built an interdisciplinary team of data scientists and […]
Read More >
Applied Surgical Robotics
Applied Surgical Robotics has developed a Robotic Surgical Assistant that creates stable and predictable surgical environments, eliminating the variation inherent with manual organ stabilization. Our proprietary platform (hardware + SaaS) is purposely designed to compliment and seamlessly integrate with other robotic devices, while using the existing instruments and end effectors that surgeons prefer.
Read More >
Carlsmed
Carlsmed is the first and only company to use patient outcome data to create personalized surgical plans and personalized implants for spine surgery. Carlsmed provides personalized solutions to decrease surgery time, decrease healthcare cost, and improve patient outcomes.
Read More >
Challenger Interactive
Challenger offers a unique on-demand approach for video gamers to compete for cash on major game titles. Challenger automates the tracking and payouts, all on a transparent and legal platform. Challenger is the first real-time in-game contest platform for the average player, offering a simple experience enhancing how players already game, giving them access to […]
Read More >
Commsafe AI
CommSafe AI is a SaaS company that specializes in conflict and violence prevention. The CommSafe AI technology flags and labels employee communication containing triggers of toxic communication. Once a communication is triggered, the technology automatically sends an alert to HR, making them aware of the otherwise hidden liability, and provides them with next step recommendations. […]
Read More >
Cytonus Therapeutics
Cytonus Therapeutics has developed a first-in-class “biologic drone” called the Cargocyte. The Cargocyte is a platform to deliver therapeutics in a precise, controlled, safe and reproducible manner. Cytonus’ innovative approach delivers on the long sought after promises of drug delivery, to deliver the right drug at the right dose to the right tissue.
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Drata
Drata is a security and compliance automation platform that continuously monitors and collects evidence of a company’s security controls, while streamlining end-to-end workflows to ensure SOC 2 audit-readiness.
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f5 Therapeutics
f5 Therapeutics harnesses the power of protein degradation to transform human health.
Read More >
Fluid Power AI
Fluid Power AI offers Reliability as a Service for the equipment that powers a $7T economy. Our IoT reliability and maintenance solution for ANY hydraulic system keeps an organization’s most valuable assets earning. Reliability as a Service is a hardware-enabled SaaS business model. Fluid Power AI provides out of the box, plug-n-play, real-time full system […]
Read More >
Fulcrum
For Fortune 1000 companies, Fulcrum’s platform enables teams to get work done faster through outside talent. Teams use one intuitive experience to form their needs, make requests, compare options (including freelancers), and ultimately drive the onboarding workflow. This means they spend less time managing the process, get faster access to better talent & focus more […]
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Galley Solutions
Galley helps restaurants, caterers, and other types of food businesses collect and understand the food data behind their operations.
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GroGuru
GroGuru supplies precision soil and irrigation monitoring and management systems to the commercial agriculture industry. GroGuru is all about strategic irrigation management. We have a patented wireless underground system (WUGS) for soil monitoring that enables the permanent installation of soil moisture sensors. GroGuru leases hardware and sell a software as a service (SaaS) product marketed […]
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HAI Solutions
HAI Solutions has developed a unique portfolio of medical devices addressing the growing plague of contamination within the operating room, emergency room and intensive care units. We are focused on launching both the MDD-Multiport Delivery Device and IVS-Intravenous Sterilizer. While these products are two separate devices, they are complimentary and tackle the arduous clinical workflows […]
Read More >
ion Learning
ion is a B2B SaaS enterprise education technology platform for developing inclusive leaders, remotely.
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Nano PharmaSolutions
Nano PharmaSolutions (NPS, a DE C-Corp) is a nanodrug delivery technology co. dedicated to providing a socially impactful solution that can rapidly bring more drugs to market. Our patent-pending platform technology generates small molecule nanoparticles for improved bioavailability of insoluble drugs. NPS is the only physical nano particle generation technology using no chemicals or solvents. […]
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Navega Therapeutics
Navega is developing epigenetic regulation gene therapies via CRISPR-dCas9 (nuclease null), and zinc fingers, for neurological disorders. Our first indication is a rare disease-Erythromelalgia-in which patients have chronic pain due to a gain-of-function mutation in Nav1.7. This same gene therapy could also be utilized for other chronic pain indications (neuropathic pain, low back pain, etc). […]
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NeuraLace Medical
NeuraLace Medical is a startup medical device company founded in San Diego whose bold mission is to disrupt the chronic pain epidemic.
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Occuspace
Occuspace is bringing the power of web analytics to the physical world. By capturing how many people are in a space, how long they stay, and where they go, Occuspace is helping clients optimize real-estate portfolios and construction, improve customer experience, reduce GHG emissions, maintain clean and safe spaces during COVID, and optimize digital ad […]
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OmniSync
OmniSync is a VC and US Air Force-backed, single sign-on software to find and fund innovation. We use AL/NLP-powered context-matching algorithms to create non-obvious connections between public/private innovators, scouts, and funders. Our flagship product, TurboSBIR helps startups connect with $4B in Federal innovation funds.
Read More >
Origami Therapeutics
Origami Therapeutics is taking a precision medicine approach to discover disease-modifying treatments for neurodegeneration caused by toxic protein misfolding.
Read More >
Pandio
Pandio is a technology company with a managed SaaS offering. We are a cloud native AI driven infrastructure play. Pandio has been specifically architected to automatically manage AI workloads enabling enterprises to optimize their data, models and tools at scale.
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Personal AI Labs
At Personal AI Labs we are solving the problem of memory recall and retention. We do this by creating your own personal AI, which is individualized and a direct reflection of you. To build your intranet of memories, we capture the memories that you talk, type or see and transform them into Memory Blocks in […]
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PetDx
PetDx – The Liquid Biopsy Company for Pets™ is a San Diego-based molecular diagnostics company dedicated to unleashing the power of genomics to improve pet health. The company’s flagship product, OncoK9™, enables veterinarians to detect cancer in dogs with a simple blood draw. As a first-in-class multi-cancer early detection (MCED) test, OncoK9 employs cutting-edge genomic […]
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PlusMusic
PlusMusic is a music technology company providing dynamic soundtracks to the gaming industry and other online experiences. Our AI and ML pipeline ingests music and turns it into soundtracks that are more useable, discoverable and valuable. Adding music to a game is legally complex, expensive and technically difficult. They need a solution that is push […]
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Shadowbox
Shadowbox is a ground-breaking, patented, secure, no-code SAAS integration platform that connects web applications without the need for APIs. Our first product was launched in late 2018 targeting interoperability in healthcare, connecting Electronic Health Records (“EHRs”) with Ancillary Healthcare Service Systems (i.e., Diagnostic Labs, Treatment Centers, Durable Medical Equipment, Hospice Care, and so on).
Read More >
South 8 Technologies
South 8 Technologies, Inc. has developed a novel Liquefied Gas Electrolyte (LiGas™) chemistry for next-generation rechargeable and primary lithium batteries and electrochemical capacitors. The LiGas electrolyte enables a wider operating temperature range of -80 to +60 °C, provides increased energy, and improved safety while maintaining compatibility with standard materials and manufacturing.
Read More >
Tag-N-Trac
Our CMaaS (Continuous Monitoring as a Service) Platform combined with our discreet Smart Sense™label technology provides the fabric for thorough supply chain visibility and real-time analytics. Our solution uniquely combines the initial process of serialization/aggregation of inventories, condition monitoring, and real-time alerts to keep track of product integrity during the chain of custody.
Read More >
The Good Face Project
The Good Face Project is an AI-Powered SaaS platform for R&D and Innovation in the Cosmetics and Personal Care Industry. We have created the LARGEST science-backed and AI-powered cosmetic ingredients ontology, with over 100,000 individual cosmetic ingredients graded across 15 dimensions of safety and efficacy.
Read More >
Thirona Bio
Deeply experienced management team focused on key diseases that impact women’s health – scleroderma and certain metastatic cancers . We are also focused on keloid scars – that disproportionately impact skin of color. These indications have no approved drugs.
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Xendee
Xendee is the world’s #1 trusted and awarded platform for certifying the resilience and bankability of distributed energy systems. Our Bankable Energy™ cloud computing platform integrates all stages of the design process in a more intelligent way that delivers unmatched speed, accuracy and confidence to our customers. Xendee patented end-end microgrid design and optimization is […]
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XILO
XILO helps insurance agencies compete against rising digital competition with an easy to use, fully customizable software platform they can use to engage with their customers, provide instant insurance quotes and automate sales workflows. As part of the next generation of agency technology, XILO is aiming to disrupt old muti-billion dollar incumbents who control the […]
Read More >2020 Cool Companies
1859
1859 is creating a pico-scale HTS platform (pico-HTS) that enables us to test millions of potential medicines in a single day. Our technology also allows us to rapidly explore chemical space and construct novel chemical diversity “on-demand”. This allows us to discover more medicines and get them to the clinic faster. At scale our technology […]
Read More >
Abterra Bio
Abterra Bio uses machine learning to mine the human immune system to discover novel antibody therapeutics. Patients mount lasting antibody responses to infectious diseases and cancer. Our platform uses next-generation sequencing and mass spectrometry data to comprehensively map this antibody response, rapidly identifying better therapeutic antibodies. We’ve built an interdisciplinary team of data scientists and […]
Read More >
Aequor
Aequor is a woman-owned small business with a large portfolio of proprietary chemical compounds discovered in the ocean that are non-toxic, “green,” and natural antimicrobials.
Read More >
Arborea
Arborea has developed the most efficient ingredients & proteins production platform that solves the crucial issues of existing photosynthetic culture platforms.
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Believe Health
Believe Health builds virtual care programs that specialty doctors can provide to their patients.
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Benchmark Labs
Benchmark Labs combines grid level weather data with site-based IoT sensors, and uses their proprietary AI software to provide precise asset-located weather forecasting to optimize renewable energy generation & water allocation, reduce spatial basis risk and maximize financial benefits.
Read More >
Biocanic
Biocanic is a HIPAA compliant Software as a Service (SaaS) integrative health and medicine platform (also known as “functional medicine”) designed to simplify personalized health plans into an easy-to-understand language for both practitioners and their clients. Biocanic digitizes all aspects of health improvement plans to build a machine learning engine. Through the Biocanic platform, we […]
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Carlsmed
Carlsmed is the first and only company to use patient outcome data to create personalized surgical plans and personalized implants for spine surgery. Carlsmed provides personalized solutions to decrease surgery time, decrease healthcare cost, and improve patient outcomes.
Read More >
Cella Medical
Cella Medical, EvoNexus portfolio company, developed a small device CELLA for personal use to reduce the number of doctor visits and hospitalizations for chronic kidney and heart failure patients. They can for the first time manage their disease by measuring fluid buildup in the comfort and privacy of their homes.
Read More >
Ceresti Health
Ceresti Health is a digital health company that specializes in the early detection and prevention of costly acute events such as emergency department visits and hospitalizations.
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Chilldyne
Chilldyne is a technology enables water to be used for direct-to-chip cooling of CPUs in high performance computers and servers.
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Circumvent
Circumvent has created a proprietary platform that identifies underlying biology that drives neurodegenerative disease in both pediatric and aging dementia patients.
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Commsafe AI
CommSafe AI is a SaaS company that specializes in conflict and violence prevention. The CommSafe AI technology flags and labels employee communication containing triggers of toxic communication. Once a communication is triggered, the technology automatically sends an alert to HR, making them aware of the otherwise hidden liability, and provides them with next step recommendations. […]
Read More >
Concert Health
Concert Health helps independent physician practices deliver integrated behavioral health services to their patients. 2019 – Raised $2.2M seed round
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Cybele Microbiome
Cybele Microbiome has a platform to harness the powerful natural factory that exists on every human: the microbiome. This is a new paradigm for producing bio-based compounds “in place” that are personalized, natural, long-lasting, vegan, sustainable, environmentally friendly, and cheaper and faster to develop than traditional industrial methods.
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Daasity
A Data-as-a-Service company that provides a proprietary end to end platform for small and medium sized direct-to-consumer companies to truly harness their data for better business decisions.
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Educational Vision Technologies
EVT uses artificial intelligence to autonomously generate online courses for universities and training programs for corporations to enable efficient learning and a substantial cost reduction for creating digital learning.
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Esguard.io
Esguard.io Corporation is all about making connecting to the Internet faster, safer, and better.
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FormAlloy
Formalloy is a 3D metal printing company which utilizes Laser Metal Deposition (LMD) technology that provides an innovative, cost-effective solution for 3D metal part production, repair and coatings to diverse industries.
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formsense
formsense technology powers the next generation of compression apparel and sports training equipment that provides the first-ever volumetric assessment of athletic form in real-time to elevate performance and prevent injuries
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Galley Solutions
Galley helps restaurants, caterers, and other types of food businesses collect and understand the food data behind their operations.
Read More >
Global BioTherapeutics USA
Global BioTherapeutics has developed a novel vector delivery method to the liver that has yielded unprecedented results, Compartmentalized Liver Transduction (CLT).
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GoShare
We use technology to improve last-mile delivery and moving experiences for our customers. Our mission is to organize the world’s trucks to make them more accessible and useful. Our vision is to create the largest network of trucks in the world. More than 90,000 customers and 12,000 Delivery Professionals trust GoShare to deliver. 2019, 2020, […]
Read More >
Gryphon
Gryphon is a cloud managed network protection platform powered by adaptive machine learning targeting the connected home and small businesses with a re-occurring business model. Gryphon combines speed, parental control, and intelligent cyber protection in a simple plug and play mesh router.
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HemaFlo Therapeutics
HemaFlo is developing a novel treatment for acute kidney injury (AKI).
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HUMBL
HUMBL LLC is a financial services company that travels with you beyond legacy systems, traditional bank branches, and physical borders. right from your mobile phone.
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Innovega
Innovega has developed a new generation of patented Contact Lenses that enable wearers to experience rich digital media experiences from stylish, lightweight Glasses.
Read More >
KAST
Your live hangout where you share your experiences. Watch movies with 100+ friends, play and share games, watch sports, hangout, and more!
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La Jolla NanoMedical
La Jolla NanoMedical is a platform product for non surgical treatment of skin cancer and certain other cancers.
Read More >
Lipidio Pharmaceuticals
Lipidio is a development stage biopharma focused on diseases associated with excess body fat.
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Lotus Trolley Bag
Lotus Trolley Bag is a reusable system & sustainable solution to plastic. In the past 2 quarters, we have grown from 600 to 10,000 retail stores in the U.S. and Canada. Experienced team, scalable model, dedicated production facility & an omnichannel sales approach. Revenue for 2019 is at $2.7M & tracking for $10M in revenue […]
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MatriSys Bioscience
MatriSys Bioscience focuses on the $142 Billion worldwide dermatology and skin care market by developing microbiome-derived therapies for the top dermatology and skin care conditions – Acne, Atopic Dermatitis (AD), Rosacea, Psoriasis, and Skin Infections which have a huge impact on 230 million patients’ quality of life.
Read More >
MediPrint Ophthalmics
MediPrint Ophthalmics (FKA Leo Lens Pharma) is an emerging San Diego-based clinical stage eye care pharmaceutical company focused on enhancing vision for life by developing and commercializing a proprietary ocular drug delivery portfolio. There are over 40 million soft contact lens wearers in the United States alone and most of them will develop some eye […]
Read More >
MemComputing
MemComputing delivers quantum computing performance to any computer with our software-based MemCPU(tm) Coprocessors. Developed at UC San Diego by two PhD Physicists.
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Micronoma
We are a team of veterans of Microbiome and Life Sciences / Biotech. We are really cool bunch of people who know how to work hard and still have fun!
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NeuraLace Medical
NeuraLace Medical is a startup medical device company founded in San Diego whose bold mission is to disrupt the chronic pain epidemic.
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NVISNx
NVISNx is an innovative cyber solutions platform developer for Fortune 500 thru emerging companies.
Read More >
Origami Therapeutics
Origami Therapeutics is taking a precision medicine approach to discover disease-modifying treatments for neurodegeneration caused by toxic protein misfolding.
Read More >
OrPro Therapeutics
OrPro Therapeutics, Inc. (San Diego, CA) is developing a therapeutic platform based on thioredoxin, a human protein disulfide-reducing enzyme with unique mucus-normalizing, anti-inflammatory and anti-infective properties.
Read More >
PhotoCulture
PhotoCulture is a curated photo contest app, designed especially for Instagram influencers and their fans. The app provides an innovative way for influencers to generate substantial income, engage with their audience in a fresh way, and provide money for the charity of their choice. PhotoCulture has phenomenal scalability; a few dozen influencer clients will result in millions of paying customers.
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Realwave
Realwave is a real-time exception monitoring and automation service that analyzes all video and associated data, alerts users to critical and interesting events, and enables users to improve their operating performance.
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Rejuvenate Bio
Rejuvenate Bio, a spinout from George Church, couples gene therapy, which makes precise biological changes with limited unintended effects, with longevity-based genes, which have the ability to affect aging and come with robust safety profiles.
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Robolink
Robolink was established in San Diego, California to encourage students to engage with STEM. We make fun and approachable robotics kits that bring computer science to life and teach real industry competency.
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Targetable
Targetable has virtualized all of the operations of a digital ad agency into one simple, easy-to-use, SaaS platform, designed exclusively for retail clients. By using a unique blend of data together with an advanced AI algorithm, Targetable automatically generates digital marketing campaigns that are faster, cost exponentially less, and perform better than a traditional agency […]
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Tempo Therapeutics
Tempo Therapeutics is a therapeutic device company creating innovative material science solutions for tissue engineering in regenerative medicine with our patent-protected MAP synthetic materials to build new functional tissue in patients and improve outcomes 10-fold over current available products.
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The Atlas
The Atlas is an online community of city officials modernizing the $1.6T local government market.
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The Crafter’s Box
The Crafter’s Box is an e-commerce marketplace for arts & crafts digital education and materials offering a 360 degree alternative to the traditional brick-and-mortar retail experience of shopping at, say, a Hobby Lobby or Michaels.
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Tiled
Tiled is a microapp platform. A microapp is an informational interactive content experience that is built without code. Tiled microapps enable sales, marketing and HR teams to have more effective conversations and communication.
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TradeSun
TradeSun is an Edison Award winning Artificial Intelligence (AI) and patent pending trade finance blockchain-enabled platform that automates the adjudication of trade finance contracts while simultaneously intercepting regulatory and fraudulent infractions.
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Trials.ai
The Trials.ai Smart Protocol solution leverages frontier technology to intelligently guide research teams through the process of designing their clinical trials, saving Pharma, Biotech & Device companies time and money.
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UCAP Power
UCAP Power, Inc. brings commercially available Ultracapacitor technology into the mainstream.
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Universal Devices
We truly believe we are nothing without our customers and our developers. We truly believe in, and practice, doing the right thing even if it's harder. And, most importantly, we are still geeks who love imagining things and bringing them into life.
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Vektor Medical
Vektor Medical is a medical technology company focused on non-invasive arrhythmia mapping for improving cardiac care and patient quality of life. Vektor’s patented vMap technology analyzes ECG signals in proprietary algorithms to provide multi-chamber 2D cardiac information and interactive 3D color maps for analysis by a physician. vMap can be used in the clinical environment, such as the EP lab and the patient’s bedside. vMap is non-invasive, rapid, and designed for the clinical workflow.
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Veriskin
Veriskin is a medical device company dedicated to facilitating and improving the accuracy of skin cancer screening.
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Vivid Genomics
Vivid Genomics is a precision medicine company dedicated to improving the success of drug development in neurodegenerative disease.
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Water Pigeon
Water Pigeon captures photos of a meter face and runs optical meter reading software to create a numerical reading for the utility.
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XILO
XILO helps insurance agencies compete against rising digital competition with an easy to use, fully customizable software platform they can use to engage with their customers, provide instant insurance quotes and automate sales workflows. As part of the next generation of agency technology, XILO is aiming to disrupt old muti-billion dollar incumbents who control the […]
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yuFlu
yuFlu is the first DTC sequencing as a service screen for COVID-19 & other respiratory infections that uses FDA-cleared collection devices.
Read More >2019 Cool Companies
Accel Robotics
Accel Robotics enables automated “Grab and Go” shopping experiences across existing and emerging store formats. Our camera-based AI system allows any shopper to enter a store, pick the items they want, then walk out receiving a receipt via text or app notification. The end result is a better, more convenient shopping experience that improves existing […]
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Apli
Apli is the fastest end-to-end solution for contingent staffing and permanent hiring in Mexico. At Apli, AI and automation create jobs by eliminating friction in permanent recruiting and turning missed days of work into temporary work opportunities. Using a chat bot to profile candidates and machine learning to constantly improve match precision, Apli is an […]
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Aquacycl
Aquacyle provides the BioElectricalchemical Treatment Technology (BETT) for onsite wastewater treatment. The BETT systems eliminate up to 80% of incoming primary sludge, recover energy as direct electricity (no methane) and can provide 90% reduction in footprint and a 50-90% reduction in operating expenses relative to conventional aerobic approaches for high-strength wastewater streams.
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Ateios
Ateios has developed a revolutionary battery technology that will reshape electronics. Primary Zinc Printable Flexible Batteries. The first all printable flexible battery with an areal capacity of 2.5 mAh/cm2. With its proprietary, platform technology based on nanocomposite ink formulation, Ateios’ first all-printed, ultra-thin, flexible battery will enable new form factors that were once unimaginable.
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Atlazo
Atlazo is the only company developing AI System-on-Chip (SoC) for healthcare enabling hearable, wearable, and battery-powered medical devices. Atlazo is bringing together cutting edge innovations in AI, Machine Learning and medical-grade bio-sensing in a single chip semiconductor device to enable health and medical device manufacturers to develop next generation products faster and at lower cost […]
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Bitmo
Bitmo is a mobile gifting platform transforming a $160 billion gift card industry. Its innovative platform allows consumers to gift easily and securely right from their mobile wallet. Unlike plastic gift cards, Bitmo is highly flexible and allows users the ability to split and even exchange card value from one store to another for free. […]
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Cardea Bio
Cardea is merging the digital and biological domains into a single system, providing for instant, immediate, and complex biochemical analysis in any setting. We do this through our patented graphene biosensor. We partner with other companies to serve multiple markets simultaneously, helping others be competitive in markets as diverse as genomics, drug testing, diagnostics and […]
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CLiCS
CLiCS has invented a hair color as a service business for professional salons. CLiCS has developed and integrated the first patented robotic hair color dispenser, The first mixable non-ammonia hair color line, the first mobile hair color design and service app and the first completely automated hair color inventory management platform and auto-pay system. The […]
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ClientPoint
ClientPoint’s top-rated proposal creation, delivery, tracking and management platform helps companies generate higher close rates and shorter sales cycles, while reducing costly proposal errors and buying salespeople more time to sell. This core offering is part of our broader mission to digitally super-empower business by bringing the best tools, technology and practices into an unequaled […]
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CourseKey
CourseKey is a b2b SaaS platform that enables education companies to digitize the collection of their academic information for analysis, intervention and audit preparation.
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Daasity
A Data-as-a-Service company that provides a proprietary end to end platform for small and medium sized direct-to-consumer companies to truly harness their data for better business decisions.
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formsense
formsense technology powers the next generation of compression apparel and sports training equipment that provides the first-ever volumetric assessment of athletic form in real-time to elevate performance and prevent injuries
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GigaIO
GigaIO enables the data center applications of tomorrow: AI/DL, the Industrial Internet of Things, Edge computing, and disaggregation, by solving the #1 compliant: interconnect performance and flexibility. The large variety of new compute and storage technologies makes demands on the interconnects that bind them together that today severely reduce system performance. Legacy interconnects were never […]
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GoMeta
GoMeta, founded by former Googler / CTO of MySpace, builds powerful platforms that make developing apps much faster, and accessible to many more people. Over 200,000 applications have been created so far, by all kinds of people from over 180 countries.
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GoShare
We use technology to improve last-mile delivery and moving experiences for our customers. Our mission is to organize the world’s trucks to make them more accessible and useful. Our vision is to create the largest network of trucks in the world. More than 90,000 customers and 12,000 Delivery Professionals trust GoShare to deliver. 2019, 2020, […]
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GoSite
GoSite provides a modern tech stack to small businesses that make it easier for their customers to find, book, and pay for their services online.
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Gryphon
Gryphon is a cloud managed network protection platform powered by adaptive machine learning targeting the connected home and small businesses with a re-occurring business model. Gryphon combines speed, parental control, and intelligent cyber protection in a simple plug and play mesh router.
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Kazuhm
Kazuhm is a next generation workload optimization platform that empowers companies to maximize all compute resources from desktop to server to cloud to Edge. Kazuhm securely and efficiently recaptures unused processing power to boost productivity and minimize unnecessary IT investment. As the first fully-connected, commercial grade compute ecosystem, it allows organizations worldwide to reduce cloud […]
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LawMatics
CRM, Intake and Marketing automation software for law firms. Manage your intake process, email and text message marketing, marketing analytics, etc help law firms get more clients and turn old business into new business.
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Lennd
Lennd is a next generation event and venue operations platform. We are centralizing and streamlining event and venue operations in order to access, manage and process the billions of dollars in internal event payments, orders, and invoices, so event teams can work smarter, move faster and increase their ROI. What Salesforce and LinkedIn have done […]
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Lynx Bio
Lynx Biosciences, Inc. is commercializing a microfluidic platform technology that is leveraging standard-of-care cancer biopsies to measure the response of a patient’s cancer cells in the context of their natural environment. Lynx Biosciences will offer this test as a service to physicians and patients, allowing them to identify them most efficacious treatment option at any […]
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MemComputing
MemComputing delivers quantum computing performance to any computer with our software-based MemCPU(tm) Coprocessors. Developed at UC San Diego by two PhD Physicists.
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NeuraLace Medical
NeuraLace Medical is a startup medical device company founded in San Diego whose bold mission is to disrupt the chronic pain epidemic.
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Qwick
Qwick connects hospitality businesses (hotels, caterers, restaurants, bars, golf courses, etc.) with food and beverage professionals on-demand to fill shifts in real-time. When a business posts a shift on our platform, we send out notifications to all the workers that meet that criteria, then workers accept the shifts they want to work, and we pay […]
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Sendlane
Sendlane is an intelligence driven, cross-channel marketing automation platform designed to empower B2C businesses to connect with customers through automated, behavior-based communications. We focus on features to help serve our core verticals which are Content Creators and eCommerce Brands in the SMB and Mid-market.
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Seraphina Therapeutics
Seraphina Therapeutics is leveraging the evolution of longevity to help people live longer, healthier lives. By upregulating mechanisms evolved in long-lived species, Seraphina has a generated a rich pipeline of promising therapeutics and novel genetic targets. Seraphina’s therapeutic candidates are being developed to treat comorbidities of aging and to slow the rate of aging itself.
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Shadowbox
Shadowbox is a ground-breaking, patented, secure, no-code SAAS integration platform that connects web applications without the need for APIs. Our first product was launched in late 2018 targeting interoperability in healthcare, connecting Electronic Health Records (“EHRs”) with Ancillary Healthcare Service Systems (i.e., Diagnostic Labs, Treatment Centers, Durable Medical Equipment, Hospice Care, and so on).
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TicketSauce
TicketSauce is a private label “Software as a Service” event management solution focusing on growing transactional revenue and data for media companies, event organizers, and convention/visitor bureaus. The complete event management platform provides the ability to control service fee related revenue and provide additional promotion for any events. Its robust, easy and fully-customizable event software […]
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Tiled
Tiled is a microapp platform. A microapp is an informational interactive content experience that is built without code. Tiled microapps enable sales, marketing and HR teams to have more effective conversations and communication.
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Trust & Will
Trust & Will is modernizing the $170B trust and estate planning industry with an easy, fast, and secure way to set up your estate plan online. Our vision is to establish Trust & Will as the category leader for a modern estate planning solution, and our mission is to help everyone leave their legacy.
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UBIQ
Ubiq is a technology company that has simplified the complex and messy world of encryption through a set of APIs, that are simple enough for any developer to use, yet scalable and extensible enough to encrypt data effortlessly across diverse applications and programming languages, cloud environments, and storage types. By enabling developers to quickly integrate […]
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Vivid Genomics
Vivid Genomics is a precision medicine company dedicated to improving the success of drug development in neurodegenerative disease.
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Voterfied
Voterfied’s participatory democracy platform bridges the communication gap between politicians and constituents by establishing an engagement hub where citizens vote on important issues, using secure blockchain technology to record their opinions. Voterfied educates citizens on the issues, allows them to be heard, encourages informed decision-making by representatives, and decreases political disenfranchisement. As an always-on virtual […]
Read More >2018 Cool Companies
Accel Robotics
Accel Robotics enables automated “Grab and Go” shopping experiences across existing and emerging store formats. Our camera-based AI system allows any shopper to enter a store, pick the items they want, then walk out receiving a receipt via text or app notification. The end result is a better, more convenient shopping experience that improves existing […]
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Additive Rocket Corporation (ARC)
With a revolutionary design for launch vehicle engines and satellite thrusters, the Additive Rocket Corporation (ARC) leverages advanced simulation and 3D metal printing to produce highly optimized propulsion systems for the space and defense industries.
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Approved
Approved is on a mission to bring transparency, efficiency and a little sanity to the mortgage experience. We build technology that agents, borrowers, lenders and their teams of loan officers and processors use everyday to streamline the back office, and provide a world class experience for borrowers. The Approved Digital Mortgage Platform allows any lender, […]
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Blueboard
Blueboard is the employee rewards and recognition platform for the modern workplace. We enable over 100 clients like Pinterest, Lyft, GoPro & Google to reward their top employees with local, curated experiences (think skydiving, Ferrari driving, Michelin-star dinners, massages, cooking classes, etc.) with just one click.
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Doctible
Doctible provides healthcare providers (Doctors, Dentists, Chiropractors, Optometrists) with marketing and automation technology solutions to help them run their business more efficiently. Founded in 2013, the company now provides a full suite of software solutions to address a providers pain points in managing its online reputation, strengthen patient communication, streamline daily operational tasks and grow […]
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DTx Pharma
DTx Pharma technology has enabled safe and effective delivery of RNA drugs to tissues like muscle, nerve and the heart.
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Epitracker
Epitracker, Inc. is unlocking secrets long held by dolphins to help treat the world’s most devastating diseases. Combining metabolomics and big data analytics, Epitracker has discovered over one hundred smart-screened small molecules targeting aging associated diseases. Our lead compound, ETI-101, has demonstrated broad efficacy in alleviating inflammation, anemia, fibrosis and metabolic syndrome. Epitracker is currently […]
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eSUB
eSUB is the only cloud-based project management software created exclusively for Subcontractors of all trades in the construction industry.
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GigaIO
GigaIO enables the data center applications of tomorrow: AI/DL, the Industrial Internet of Things, Edge computing, and disaggregation, by solving the #1 compliant: interconnect performance and flexibility. The large variety of new compute and storage technologies makes demands on the interconnects that bind them together that today severely reduce system performance. Legacy interconnects were never […]
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GroGuru
GroGuru supplies precision soil and irrigation monitoring and management systems to the commercial agriculture industry. GroGuru is all about strategic irrigation management. We have a patented wireless underground system (WUGS) for soil monitoring that enables the permanent installation of soil moisture sensors. GroGuru leases hardware and sell a software as a service (SaaS) product marketed […]
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Gryphon
Gryphon is a cloud managed network protection platform powered by adaptive machine learning targeting the connected home and small businesses with a re-occurring business model. Gryphon combines speed, parental control, and intelligent cyber protection in a simple plug and play mesh router.
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Home Bay
Home Bay, a San Diego based company, provides consumers a smarter and easier way to buy and sell homes without commissions, saving home buyers and sellers an average of $16,000 per transaction. We provide traditional services such as pricing strategy, negotiation and closing management along with professional photography, an installed yard sign and exposure across […]
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Hookit
A pioneer in the sponsorship technology space, Hookit is the global standard for quantifying sports sponsorship value across social, digital and traditional media. Hookit works with brands and rights holders to empower them to buy & sell sponsorships more effectively. With Hookit data, rights holders can prove the value they bring to sponsors. For brands, […]
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Iteros
Iteros is a software company on a mission to create smarter, more reliable, more sustainable energy grid. Their energy management system makes it easy to design, integrate, and operate energy assets like solar and battery storage devices. The platform provides an end-to-end platform that allows their customers to easily model and simulate changes to a […]
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Lab Fellows
LabFellows provides SaaS workflow automation tool for life sciences operations. We believe scientists developing medical breakthroughs shouldn’t have to spend 42% of their day on lab administrative tasks to meet compliance, logistics, and procurement needs of life science companies. Before LabFellows, they had to. Our platform and proprietary FUSION technology streamlines 17 hours a week […]
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Measurabl
Measurabl is the world’s fastest-growing sustainability software for the built environment. Our automation tools make it easy and accurate for more than 5 billion square feet of commercial property across 67 countries to collect sustainability data, analyze, and report on performance, and identify energy and water efficiency opportunities. Learn more about Measurabl at www.measurabl.com.
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MedCrypt
MedCrypt has developed a security toolkit that allows medical device developers to focus on diagnosing and treating disease, while ensuring their devices comply with security best practices. And since each installation of our software will communicate with our MedCrypt network, we can use machine learning-based transaction monitoring algorithms to detect anomalous behavior, thwarting attacks in […]
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Notogen
Notogen is a biotechnology company creating regenerative therapeutics for spine, orthopedic and sports medicine related conditions. Starting with Degenerative Disc Disease (DDD), Notogen’s initial product is an intradiscal injection consisting of two growth factors belonging to unique families of proteins. This groundbreaking therapeutic is based on more than 18 years of award winning research and […]
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Omnics
Omnics provides supply chain planning software solutions that help companies make sound, data-driven, timely decisions while transforming its data into a competitive asset. Omnics automates your supply chain planning processes and uses AI-enabled applications for strategic and tactical planning . Omnics software platform’s suite of capabilities include extracting, processing, analyzing and collaborating supply chain planning […]
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OrPro Therapeutics
OrPro Therapeutics, Inc. (San Diego, CA) is developing a therapeutic platform based on thioredoxin, a human protein disulfide-reducing enzyme with unique mucus-normalizing, anti-inflammatory and anti-infective properties.
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PayRent.com
In an increasingly digital world, PayRent.com provides a payment technology platform for landlords that manage 1 or multiple rental properties to accept rent online. Tenants and their roommates can setup automatic bank transfers or pay rent with a credit card, earning points and rewards along the way. We provide industry specific tools for landlords, unlike […]
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Primo Energy
Primo Energy produces alternative energy systems that incorporate wind, solar and batteries for a complete nanogrid operation. (formerly Primo Wind)
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SenseMetrics
Sensemetrics transforms industrial sensor data into leading risk management and safety solutions for the largest companies in the world. We understand the issues posed by legacy infrastructure in the industrial arena and have built our software platform to intelligently consolidate and connect to disparate information sources so that clients may garner what they seek out […]
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Smart Shelf
The AWM SMART SHELF is designed to replicate key benefits of the online experience into physical retail environments. The platform utilizes ruggedized shelf-edge displays combined with high definition optical sensors to automate intelligence into on-the-shelf inventory levels and planogram compliance, play optimal video based on shopper distance (including product pricing and information), provide insight into […]
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Sourcify
Sourcify is the fastest growing sourcing platform backed by Y Combinator that helps hundreds of companies manufacture products around the world. Our platform adds visualization, transparency, and trust to the manufacturing world, enabling companies to produce product more cost effectively and faster than ever.
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Trials.ai
The Trials.ai Smart Protocol solution leverages frontier technology to intelligently guide research teams through the process of designing their clinical trials, saving Pharma, Biotech & Device companies time and money.
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Triton Algae Innovations Ltd.
Triton provides novel solutions for the world’s food shortages and has ushered the microalgae through the GRAS process. The miroalgae tastes great and is rich in plant proteins, omega oils and vitamin A. Triton has developed scalable, environment-friendly manufacturing processes, demonstrated benefits to gut health, and pioneered biotechnology tools to produce nutritional compounds for future […]
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Trust & Will
Trust & Will is modernizing the $170B trust and estate planning industry with an easy, fast, and secure way to set up your estate plan online. Our vision is to establish Trust & Will as the category leader for a modern estate planning solution, and our mission is to help everyone leave their legacy.
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Truvian Sciences
Truvian is working to empower consumers to manage, track, and own their personal health data. Using our technology, consumers can order a panel of tests, provide a small blood sample, and receive results in minutes directly on their smartphone. By making the testing convenient and affordable, Truvian will move from spot check diagnostic testing to […]
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Uqora
Uqora is a vaginal health company that has started by tackling urinary tract infections (UTIs). UTIs are the second most common infection in the U.S., responsible for more doctors visits per year than everything but the common cold. Despite the magnitude of the problem, the focus has long been on treatment instead of prevention. Uqora […]
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Wildfire Systems
Wildlink’s patent pending systems use artificial intelligence and natural language processing to detect product recommendations within all forms of digital communications and transform them into links to online stores from our network of over 20,000 merchants. When a user recommends a product, the platform automatically creates a Wildlink which points to the retailer’s product page. […]
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Yembo
Yembo is building computer vision and AI technology that makes the shopping process for the 40M Americans who relocate from a stressful, time consuming and fragmented experience into a interactive process that takes only a few minutes.
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Yobi
Yobi is the first cannabis-specific retail operations platform built by retail technology experts. The Yobi platform was designed and built from the ground up leveraging the methodologies employed by global brands, but engineered specifically for dispensary operations. By offering enterprise solutions with an intuitive user interface, our clients experience a significant reduction in training time, […]
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Zebit
Zebit was founded to provide radically better financial options for all consumers. With over 100 million credit-challenged U.S. Adults struggling to financially stay afloat, Zebit is the first to offer up to $2,500 of interest-free credit at 0% APR to all members without a credit check. Members can shop millions of name brand products in […]
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Zesty.io
Zesty.io is fast-forwarding the next generation of cloud-based web content management systems (WCMS) for marketers and developers of mid-market and enterprise organizations. With its 100% native SaaS content management system (CMS), global customers like Sony Electronics, Acorns.com, Rocket League, Astroglide and Hofbruhaus are speeding, scaling and securing global distribution and website management of digital content.
Read More >2017 Cool Companies
Abreos Biosciences
Biologic drugs are life-saving drugs that effectively treat serious illnesses including cancer and autoimmune diseases. However, dosing is usually one-dose-fits-all and the costs are becoming unsustainable. As a result, patients are not getting the most from their treatment. Abreos Biosciences is poised to have a major impact on the delivery of biologic drugs by offering […]
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Accel Robotics
Accel Robotics enables automated “Grab and Go” shopping experiences across existing and emerging store formats. Our camera-based AI system allows any shopper to enter a store, pick the items they want, then walk out receiving a receipt via text or app notification. The end result is a better, more convenient shopping experience that improves existing […]
Read More >
Additive Rocket Corporation (ARC)
With a revolutionary design for launch vehicle engines and satellite thrusters, the Additive Rocket Corporation (ARC) leverages advanced simulation and 3D metal printing to produce highly optimized propulsion systems for the space and defense industries.
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Allbound
More than 100,000,000 business around the world sell through indirect channels and partner programs – yet for decades, they’ve had to rely on cobbled-together partner portals and legacy partner management systems. Allbound’s replaces partner portals and PRM with a smart, data-driven SaaS platform that automatically guides partners to more closed deals and renewals while delivering […]
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Amydis Diagnostics
Amydis Diagnostics, Inc. is a preclinical stage, privately-held pharmaceutical company founded in 2013 that is developing proprietary chemistry licensed out of UCSD using innovative approaches to detection of amyloid-related disorders. The Company’s lead program is addressing an important problem in today’s society regarding the clinical need for diagnostic testing of Alzheimer’s disease in its early […]
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Approved
Approved is on a mission to bring transparency, efficiency and a little sanity to the mortgage experience. We build technology that agents, borrowers, lenders and their teams of loan officers and processors use everyday to streamline the back office, and provide a world class experience for borrowers. The Approved Digital Mortgage Platform allows any lender, […]
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BenRevo
We realized that while individuals and small employers had online platforms to purchase insurance, midsize to large employers and the brokers that served them still found themselves using paper. To solve for this massive market need BenRevo has created sales automation software designed specifically for insurance companies. We help insurance companies automate their sales process […]
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Brax Software
Content Distribution and Automation Platform. Brax.io enables advertisers to create campaign creatives once then syndicate across multiple content advertising sources eliminating hours of repetitive work. In addition it attributes engagement; revenue across multiple dimensions for a clear picture of return on marketing investment. Unlike search and social which are each dominated by one company, massive […]
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Brojure
20 years ago I stopped writing proposals because no one would read them….so I started using 20X30 storyboards to get my ideas across. Our win ratio went to 98% using stunning visuals and grew my second company to $120 Million in sales in 4 years. Brojure was developed to allow you to create Vogue-like proposals […]
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CourseKey
CourseKey is a b2b SaaS platform that enables education companies to digitize the collection of their academic information for analysis, intervention and audit preparation.
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CureMatch
CureMatch’s decision support system guides oncologists in the selection of combinations of cancer drugs that are personalized for individual patients, based on the molecular profile of the patient’s own tumor. The CureMatch platform, with a foundation in oncology, genetics, proteomics, biochemistry, and cell biology was originally developed and licensed by a multidisciplinary team at UC […]
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Direct Cannabis Network
Direct Cannabis Network is the leading digital news network highlighting the latest tech, entrepreneurs and innovative companies in the cannabis industry. DCN’s mission is to build an ecosystem for the entrepreneurial community that provides a voice for the startups, a platform for the professionals and a community for the entrepreneurs through the form of quality […]
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Doctible
Doctible provides healthcare providers (Doctors, Dentists, Chiropractors, Optometrists) with marketing and automation technology solutions to help them run their business more efficiently. Founded in 2013, the company now provides a full suite of software solutions to address a providers pain points in managing its online reputation, strengthen patient communication, streamline daily operational tasks and grow […]
Read More >
Epitracker
Epitracker, Inc. is unlocking secrets long held by dolphins to help treat the world’s most devastating diseases. Combining metabolomics and big data analytics, Epitracker has discovered over one hundred smart-screened small molecules targeting aging associated diseases. Our lead compound, ETI-101, has demonstrated broad efficacy in alleviating inflammation, anemia, fibrosis and metabolic syndrome. Epitracker is currently […]
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Fantasy Sports Co.
Fantasy Sports Co. is a mobile-first company focusing on the sports/leisure vertical. We’re proud to make LineStar the world’s leading Daily Fantasy Sports Analytics Platform which is available for free on both Android/iOS. All our apps are developed 100% in-house in Carlsbad, CA. Stay tuned for what’s next, we’re working on the next hit app!
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Grolltex
Grolltex, for ‘graphene-rolling-technologies’, leverages research from the University of California, San Diego’s Nano-engineering Dept., that enables the practical and sustainable manufacture of the ‘wonder material’, graphene. This next generation material will be used for advances in flexible electronics, wearables, water desalination, life saving biosensors, and much more.
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Guru
Guru is the technological bridge between cultural institutions and a 21st-century audience. We make the museum experience interactive, immersive, and compelling for visitors both inside and outside museums, zoos, and aquaria. How do we do this? We tell stories. Through virtual reality, augmented reality, audio, and video we turn the ever-present smartphone into a personal […]
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Industry
Industry is a professional network and hiring platform (think LinkedIn) exclusively for the service and hospitality industry (restaurants, bars, clubs, and hotels). The company has already gained traction with giants in the industry, with a client list that includes MGM Resorts International, Stone Brewing Co, among others.
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KLOTHO Therapeutics
KTI, a virtual biotech company, has filed patents on modified KLOTHO proteins with great potential to positively impact aging, cognition, kidney function, fibrosis and cancer. KTI is well positioned to enter human trials within 2 years focused on its first indication: acute kidney disease, which kills 300k/year and represents a $2B market opportunity in U.S. […]
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LoanHero
LoanHero provides financing for important things in life. Whether it’s a medical procedure not covered by insurance or a new roof, we’re there to cover expenses over $1,000. Our innovative financing platform empowers merchants to extend instant financing at the point of sale. With multiple lenders in a simple application, consumers receive the best loan […]
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Measurabl
Measurabl is the world’s fastest-growing sustainability software for the built environment. Our automation tools make it easy and accurate for more than 5 billion square feet of commercial property across 67 countries to collect sustainability data, analyze, and report on performance, and identify energy and water efficiency opportunities. Learn more about Measurabl at www.measurabl.com.
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MemComputing
MemComputing delivers quantum computing performance to any computer with our software-based MemCPU(tm) Coprocessors. Developed at UC San Diego by two PhD Physicists.
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Molecular Assemblies
Molecular Assemblies, Inc. is a San Diego-based company developing a revolutionary, enzymatic DNA synthesis technology capable of powering new products in industrial synthetic biology, personalized therapeutics, precision diagnostics, and eventually information storage, nanotechnology and more. Inspired by nature, the company’s proprietary DNA synthesis method is designed to produce long, high quality, sequence-specific DNA reliably, affordably […]
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NanoCellect Biomedical
NanoCellect is a life science startup manufacturing cell sorters that use proprietary microfluidic technology. NanoCellect’s WOLF cell sorter and single cell plate dispenser allows researchers to perform antibody discovery, cell line development, genomic sample prep and CRISPR genomic editing faster, safer, and without contamination. The compact, sturdy, and affordable system allows researchers to safely perform […]
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Nanome
Nanome’s mission is to build intuitive tools that aid in the progression of molecular precision and advancements of nanotechnology to inspire innovative breakthroughs starting with the life sciences and then expand across every industry. They are working closely with research institutions and one of the top 5 pharmaceutical companies to improve their visualization, collaboration, and […]
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Orison
Orison is an energy storage company developing the first plug-and-play battery system for single and multi-family housing, and light commercial uses. We have developed an appliance based, low cost, scalable, lightweight and Internet of Things/Cloud management approach to energy storage. Orison enables all electric consumers to control their electricity use and to save money, while […]
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PathSense
PathSense powers location for many top “uber” type apps, home automation platforms, insurance platforms, fleet platforms, advertising platforms, and more. – Geofencing, 2x as fast, 2x as accurate – Activity recognition, 6x as fast, 40% the battery drain – Location accuracy, PathSense is 99% accurate even in cities with tall buildings, compared to 22% for […]
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PetDesk
We are PetDesk and we build technology for the care providers of the best beings in the world – our pets. We help keep them healthy, happy, and give them more time to play with their owners – us! We treat our local business customers like family. We stand up for them in the face […]
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Qelzal
Qelzal invented a new technology that lets commercial drones safely fly faster and farther without crashing. Qelzal delivers a true autonomous UAV Sense and Avoid system using Image Free Sensing combined with brain-inspired artificial intelligence for rapid response and collision avoidance. Our intelligent eyes perceive objects, determine if they are a threat, then plan a […]
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Sun Genomics
Using DNA analysis technology, Precision Probiotics empowers consumers to take the guess work out of benefiting from a probiotic. Simply order our kit, test your microbiome, and begin our precision probiotic formula. Our tailored probiotic targets your specific dysbiosis – when one’s gut microbes have shifted from helpful to harmful.
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TRUEPIC
TRUEPIC is an image; video authenticity platform. TRUEPIC’s patented technology acts as a notary for digital photos, driving confidence among consumers and businesses that a shared photo has not been altered in any way.
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Veyo
At Veyo, we envisioned a better system for patient transportation one where ridesharing and advanced tracking and analytics would dramatically improve service quality, efficiency, and transparency. Our revolutionary business model, built with technology and analytics at its core, provides a full array of NEMT benefit management services to our health plan customers. Together, we are […]
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Xycrobe Therapeutics
Xycrobe’s technology platform addresses the need of patients with inflammatory skin disease through the development of a library of good bacteria strains designed to be used for therapeutic purposes. With our technology, we aim to change the way inflammatory skin disease is treated by 1) addressing bacterial dysbiosis of the skin, 2) addressing immunological or […]
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Yembo
Yembo is building computer vision and AI technology that makes the shopping process for the 40M Americans who relocate from a stressful, time consuming and fragmented experience into a interactive process that takes only a few minutes.
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Zesty.io
Zesty.io is fast-forwarding the next generation of cloud-based web content management systems (WCMS) for marketers and developers of mid-market and enterprise organizations. With its 100% native SaaS content management system (CMS), global customers like Sony Electronics, Acorns.com, Rocket League, Astroglide and Hofbruhaus are speeding, scaling and securing global distribution and website management of digital content.
Read More >2016 Cool Companies
Approved
Approved is on a mission to bring transparency, efficiency and a little sanity to the mortgage experience. We build technology that agents, borrowers, lenders and their teams of loan officers and processors use everyday to streamline the back office, and provide a world class experience for borrowers. The Approved Digital Mortgage Platform allows any lender, […]
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AttackIQ
AttackIQ purpose-built the FireDrill SaaS platform to easily integrate into any existing network to almost immediately identify security gaps and provide actionable insight to improve your security posture.
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Brojure
20 years ago I stopped writing proposals because no one would read them….so I started using 20X30 storyboards to get my ideas across. Our win ratio went to 98% using stunning visuals and grew my second company to $120 Million in sales in 4 years. Brojure was developed to allow you to create Vogue-like proposals […]
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Camston Wrather
Camston recycles gold and precious metals from electronic waste using a two-stage non-toxic proprietary green technology. The process is low cost and generates positive cash flow in the first month after the completion of each processing system. Currently, 270 tons of gold per year is diverted to developing countries or thrown directly into U.S. landfills.
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CircleShout
We deliver software proven to increase sales and reduce costs through national customer rollout. On April 11th launched with the worlds’ largest restaurant chain at their worldwide convention. This is a comprehensive digital platform solution with hyper-local consumer engagement, actionable analytics, store energy savings, asset management, and soon IoT.
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Cordial.io
Cordial is a next-gen behavioral messaging platform designed to allow smart marketers to engage and connect with consumers across all digital media in real-time. Cordial offers messaging powered by customer behavior so companies can capture and respond to every digital interaction and connect to customers in the moment, on any digital device, ensuring high value […]
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CourseKey
CourseKey is a b2b SaaS platform that enables education companies to digitize the collection of their academic information for analysis, intervention and audit preparation.
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CureMatch
CureMatch’s decision support system guides oncologists in the selection of combinations of cancer drugs that are personalized for individual patients, based on the molecular profile of the patient’s own tumor. The CureMatch platform, with a foundation in oncology, genetics, proteomics, biochemistry, and cell biology was originally developed and licensed by a multidisciplinary team at UC […]
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Dermala
We have 10 times more microbes than human cells and 100 times more microbial genes than human genes. The human microbiome (collection of all microbes) is a fundamental part of our physiology. Dermala is pioneering unique human microbiome-based drug discovery and development. Our approach is based on previously unexplored aspect of the microbiome metabolome (collection […]
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eSUB
eSUB is the only cloud-based project management software created exclusively for Subcontractors of all trades in the construction industry.
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Feetz
We make 3D Printed shoes that are custom fit and styled using your smartphone. Amazing technology that wows customers in watching a shoe being “born”. We solve a big problem (fit) in a big global market ($20bn) with key patented technology (5 patents) with an awesome team… and make revenue.
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Forge Therapeutics
We are developing a novel antibiotic to treat infections caused by drug resistant Gram-negative bacteria where treatments no longer exist. The target, LpxC, has been worked on by large pharma for decades but failed due to limitations with their metal binding chemistry. Pharma has optimized 90% of the chemistry and we have solved the remaining […]
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Lab Fellows
LabFellows provides SaaS workflow automation tool for life sciences operations. We believe scientists developing medical breakthroughs shouldn’t have to spend 42% of their day on lab administrative tasks to meet compliance, logistics, and procurement needs of life science companies. Before LabFellows, they had to. Our platform and proprietary FUSION technology streamlines 17 hours a week […]
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LeadCrunch
LeadCrunch is cool because it empowers small and medium size business to find new customers using cutting edge artificial intelligence. Think of LeadCrunch as David’s slingshot for outbound sales teams to beat Goliath incumbents. Our customers get 3x to 6x improvement in lead quality. That is why we grew by more than 90% in every […]
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Leading Biosciences
Leading BioSciences is advancing a novel therapeutic to address conditions that result from the breakdown of the intestinal mucosal barrier. Now in advanced clinical testing, LB1148 is designed to prevent postoperative ileus and surgical adhesions, reduce complications from cardiovascular surgery and stop multiple-organ failure from acute shock.
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LoanHero
LoanHero provides financing for important things in life. Whether it’s a medical procedure not covered by insurance or a new roof, we’re there to cover expenses over $1,000. Our innovative financing platform empowers merchants to extend instant financing at the point of sale. With multiple lenders in a simple application, consumers receive the best loan […]
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Lymber
Lymber helps you find the classes and activities that best fit your lifestyle, with results based on your location and unique preferences. With Lymber, you can now enjoy the best in fitness and wellness without costly monthly membership fees and restrictions.
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MindTouch
MindTouch is a cloud-based software helping companies take the product content they already produce and turn it into a customer engagement channel that educates buyers and creates product experts to grow revenue.
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Molecular Assemblies
Molecular Assemblies, Inc. is a San Diego-based company developing a revolutionary, enzymatic DNA synthesis technology capable of powering new products in industrial synthetic biology, personalized therapeutics, precision diagnostics, and eventually information storage, nanotechnology and more. Inspired by nature, the company’s proprietary DNA synthesis method is designed to produce long, high quality, sequence-specific DNA reliably, affordably […]
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Robo 3D
We built our first 3D printer in 2013 and launched it on Kickstarter raising $650,000 in preorders in 30 days. Now our product is in 2400 cities across 96 countries helping people bring their ideas to life.
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Secured Universe
We STOP malware (threats disguised as legitimate apps) on the 2 billion devices powered by Android. Unlike everyone else, our BiTSentry technology doesn’t detect or predict anything, it isolates and mitigates the risk of malware from the bottom up. The core technology will be extended beyond mobility to secure the Internet of Things (IoT). We […]
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Siragen Pharmaceuticals
Siragen Pharmaceuticals is a drug discovery and development biotechnology company, focused on novel approaches to treat Aging and Neurodegenerative Disorders such as Alzheimer’s disease. Siragen is developing a group of small lead molecules that tackles Alzheimer’s disease by novel strategy different from current unsuccessful approaches.
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SkySafe
SkySafe is focused on the growing public safety and privacy threats caused by consumer drones. We’re the first complete solution for detecting, identifying, tracking, and mitigating malicious drone activity. This last year has seen a rise in drone threats to airports, stadiums, prisons, border protection, and many more critical air spaces. SkySafe is helping those […]
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SparkFin
Stock market research is bland and tedious so SparkFin has set out to change the industry. SparkFin allows users to quickly find the best stock ideas by providing professionally curated stock lists based on market themes, current trends, and popular topics reducing research from hours to a few seconds.
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StemoniX
StemoniX is setting a new economic paradigm around stem cell technologies to meet the demands of drug discovery and personalized medicine.
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SweetLabs
SweetLabs is an app install platform that helps developers reach millions of new users, while enabling device manufacturers to better monetize and differentiate their products. SweetLabs powers dynamic app delivery across Android and Windows devices, getting the right app to the right user on the right device.
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Tourmaline Labs
Tourmaline Labs, Inc. provides location and behavior monitoring services to phone app developers, carriers and manufacturers in the US, Europe, and Asia.
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TruMed Systems
We have created the worlds first fully automated vaccine storage and handling system. Our system does a superior job maintaining proper temperature compared to traditional refrigerators. The system is cloud controlled and automates reporting and tracking that nurses do manually today.
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Venue Report
The Venue Report is COOL because we believe in trusted curation, quality over quantity and connecting people with extraordinary places and experiences. We promote gatherings, the oldest tradition in humankind, bringing people together to celebrate moments in their life that often times they will remember for the rest of their life.
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Wildcat Discovery Technologies
Wildcat is a group of scientists and engineers developing better Lithium Ion battery technologies. Our discoveries are used in batteries to power computers, cell phones, medical devices, and cars. We use drug discovery techniques, high throughput combinatorial chemistry, and apply these to the discovery of new battery materials. We out-license our discoveries, so our business […]
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Wrapify
We put cash back into the pockets of everyday American commuters. We have maintained triple digit month over month and we are nearing a $3M revenue run rate.
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XY Findables
Webble is now XY Findables. XY Findables already has customers all over the world using our Bluetooth item finders on everything from Ferrari keys to surfboards to diaper bags. In 2016, we’re expanding our product line with a GPS unit, NFC stickers, and upgraded hardware in our Bluetooth devices. (Formerly Webble)
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Xycrobe Therapeutics
Xycrobe’s technology platform addresses the need of patients with inflammatory skin disease through the development of a library of good bacteria strains designed to be used for therapeutic purposes. With our technology, we aim to change the way inflammatory skin disease is treated by 1) addressing bacterial dysbiosis of the skin, 2) addressing immunological or […]
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Zebit
Zebit was founded to provide radically better financial options for all consumers. With over 100 million credit-challenged U.S. Adults struggling to financially stay afloat, Zebit is the first to offer up to $2,500 of interest-free credit at 0% APR to all members without a credit check. Members can shop millions of name brand products in […]
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Zingle
From ringing bells with every sales deal, to surf board racks and foosball in the warehouse, Zingle is very proud of their culture with every day. We work hard and have fun in the process. Every day is a little more fun and because messaging is SO COOL right now… Zingle goes hand in hand […]
Read More >2015 Cool Companies
451 Degrees
Consumers comment on content from thousands of places such as News sites, Amazon, Yelp, YouTube as well as through Twitter, Facebook, Instagram, Google+ and others. How do you make comments, Big Data, matter and not just focus on simple Sentiment Analysis? Meet Graffiti, a Big Data Software as a Service (SaaS) for all content that […]
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Antenna79
Antenna79’s patented technology maximizes RF performance of wireless devices. We design cell phone cases with built-in antenna technology that work with the antennas inside smartphones to create larger, improved antenna systems. Our ReachAntenna product is available nationwide in all Best Buy locations. Antenna79’s management team comes from Qualcomm and LifeProof and our technical team includes […]
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Boost Academy
Boost Academy offers students one-on-one math tutoring over the iPad. The company’s patent-protected platform provides a rich, fully interactive learning environment for students who are able to conveniently connect with their own subject-certified, personal tutor. The app converts the iPad into a two-way, real-time whiteboard. Students and tutors work through problems together as though they’re […]
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CleverPet
Dogs are sad and lonely for 10s of billions of hours each year, and those who care about them feel so guilty they’ll spend $40/day and drive their pet to a “dog daycare”. The pet market has grown to nearly $60B/year, and there are now more dogs in the US than people under age 20. […]
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Cloudbeds
Cloudbeds creates browser-based hospitality management software that simplifies the working life of hoteliers. Cloudbeds’ award-winning software is trusted by thousands of hotels, hostels, and groups in over 115 countries. With over 300 integrations, Cloudbeds connects to more marketplaces than any software in this industry.
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Companion Medical
Companion Medical was founded with the idea that while insulin pumps are the best therapy you can provide for an insulin using diabetic, only 7% of patients choose to use them because of their cost and challenges. By adding Bluetooth to an insulin pen, we have brought the benefits of insulin pump therapy like dose […]
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CoreTechs Labs
Dramatically improve the diagnosis, early detection and personalized treatment of key brain disorders by bringing innovative brain image analysis software solutions to clinical practice. Our software solution NeuroQuant automatically segments, classifies and quantifies the volumes of sub-cortical brain structures. It then compares them to normative values by age and gender, and provides reports to neurologists […]
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CureMetrix
CureMetrix has developed an amazing technology. An algorithm more powerful than anything else on the market. Development of the CureMetrix technology began in 2004 and our algorithm was first deployed at NASA in 2006. Since that initial contract with NASA to help predictably model space weather, we’ve deployed our algorithm into 8 different domains for […]
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CyberFlow
CyberFlow Analytics develops FlowScape software that delivers continuous cyber security threat assessment and monitoring at scale using unsupervised machine learning and behavioral analytics. CyberFlow technology is focused on detection of Advanced Persistent Threats (APTs) and cyber breaches for the enterprise security market and the Industrial Internet of Things. The company has termed the expression analytics […]
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FuelRod
FuelRod offers a world-first, on-the-go power solution for users of mobile devices (smartphones, tablets, etc.) so that they can enjoy continuous, untethered power anytime, anywhere. With 7 billion mobile devices worldwide, the market for mobile chargers is estimated to be $7B in the US alone. We intend to become a market leader by introducing a […]
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Holonis
Holonis is the solution for anyone to become successful online. Our goal is to unleash human creativity by giving the opportunity for all users to transform their passions into an opportunity that they can profit from. The Holonis platform enables users to tell their story by connecting the tools they need for content, commerce, distribution, […]
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Human Longevity Inc.
Cypher Genomics is now Human Longevity Inc. It is a leading genome informatics company offering a highly accurate, rapid and robust interpretation software solution for users of human genome sequencing. The proprietary, automated genomic interpretation platform allows clinical laboratories to tune Human Longevity Inc. market leading sensitivity and specificity profiles to develop molecular tests for […]
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Lawn Love
Lawn Love is an on-demand lawn care company. We’re Handy/Homejoy for everything outside the walls. At $74B/year, the lawn care market is huge, and over 80% of American households have a lawn. The market is low-tech, highly fragmented, and the current customer experience is terrible. We’re bringing software and smart operations to the space, which […]
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Molecular Assemblies
Molecular Assemblies, Inc. is a San Diego-based company developing a revolutionary, enzymatic DNA synthesis technology capable of powering new products in industrial synthetic biology, personalized therapeutics, precision diagnostics, and eventually information storage, nanotechnology and more. Inspired by nature, the company’s proprietary DNA synthesis method is designed to produce long, high quality, sequence-specific DNA reliably, affordably […]
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Portfolium
Portfolium is a website and iOS app solving the LinkedIn and resume problem employers experience when recruiting college students and recent grads due to their limited professional work history. It’s an academic e-portfolio network for millennials across all fields of study to visually showcase their work, projects and skills to employers and hiring managers. By […]
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