Since 2015, Cool Companies have raised over $730M
(just in Series A)
Thank you to the Cool Companies 2022 Sponsors
Announcing the Cool Companies of 2022!
Every year we gather applications from tech and lifesci startup companies around the region and select the COOLEST COMPANIES to introduce to VCs across the country.
- All
- Tech
- LifeSci
- Consumer
Abilita Bio
Abilita Bio is a biotechnology company focused on enabling discovery and development of drugs targeting membrane proteins, including G Protein Coupled Receptors (GPCRs) and ion channels.
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Advanced Image Robotics
AIR is building remote video capture, storage, and distribution solutions for the Digital Age. The AIR platform marries robotics, machine-intelligence, and an intuitive interface to simplify high-end camera control and reduce production costs.
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Aeromutable
Aeromutable has developed a non-intrusive add-on system that, through the use of air injection, significantly improves aerodynamic performance and reduces fuel consumption and carbon emissions of trucks.
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Applied Surgical Robotics
Applied Surgical Robotics has developed a Robotic Surgical Assistant that creates stable and predictable surgical environments, eliminating the variation inherent with manual organ stabilization. Our proprietary platform (hardware + SaaS) is purposely designed to compliment and seamlessly integrate with other robotic devices, while using the existing instruments and end effectors that surgeons prefer.
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Benchmark Labs
Benchmark Labs combines grid level weather data with site-based IoT sensors, and uses their proprietary AI software to provide precise asset-located weather forecasting to optimize renewable energy generation & water allocation, reduce spatial basis risk and maximize financial benefits.
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BetFully
BetFully is a new Universal Gambling Rewards program for the rapidly growing online sports betting industry. Millions of sports bettors participate on a regular basis and BetFully gives them up to 10% cashback on their deposits and betting whether they win or lose. Users also have access to premium sports data for free, a $1,200 […]
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CARI Health
CARI Health is developing the next generation of Remote Medication Monitors that will allow clinicians to prescribe medications and receive real-time reporting on medication levels. CARI’s small, wireless sensors are worn on the patient’s skin and continuously monitor medication levels, sending alerts when necessary. With a CARI Remote Medication Monitor clinicians can provide precision care […]
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ChargeNet Stations
ChargeNet Stations helps Quick Serve Restaurant (QSR) owners integrate, and extend, food sales into the parking lot via EV Fast Charging and renewable power infrastructure. Our ChargeOpt hardware-agnostic SaaS platform optimizes EV chargers and renewable energy turning parking lots into profit centers.
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Commsafe AI
CommSafe AI is a SaaS company that specializes in conflict and violence prevention. The CommSafe AI technology flags and labels employee communication containing triggers of toxic communication. Once a communication is triggered, the technology automatically sends an alert to HR, making them aware of the otherwise hidden liability, and provides them with next step recommendations. […]
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Cooler Heads
Cooler Heads has developed a cold cap, FDA approved, to help cancer patients keep their hair while undergoing chemotherapy
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CRISPR-QC
CRISPR QC will become the standard by which CRISPR based therapeutics and other applications are measured, audited and guaranteed for high quality, effective outcomes.
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Defined Bioscience
Defined Bioscience is a San Diego-based startup focused on making robust, fully-defined, high-quality ingredients for stem cell culture, with applications in the life science, biopharmaceutical, and cultured meat sectors.
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DockWorks
DockWorks’ mission is the mobilization and modernization of the marine services industry. Our vision is a full-service operations platform that enables marine professionals to manage, optimize and scale their business.
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EndoCyclic Therapeutics
EndoCyclic Therapeutics is a biopharmaceutical company engaged in the development of the first non-hormone therapeutic for endometriosis.
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Endure Biotherapeutics
Endure Biotherapeutics is developing engineered engraftable live biotherapeutics for gastrointestinal diseases by genetically engineering man’s native bacteria to express therapeutic compounds (such as anti-inflammatory cytokines).
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f5 Therapeutics
f5 Therapeutics harnesses the power of protein degradation to transform human health.
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FAScinate Therapeutics
FAScinate Therapeutics are developing novel drugs for CNS disease area. Our KM-819 is a First-in-Class, Disease modifying drug candidate for neurodegenerative diseases such as Parkinson’s disease and Multiple System Atrophy to stop or slow down the disease progression.
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Fenix Space
Fenix Space is developing the next-generation air-launch platform to deliver payload to low earth orbit at a fraction of the cost of current solutions.
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Fluid Power AI
Fluid Power AI offers Reliability as a Service for the equipment that powers a $7T economy. Our IoT reliability and maintenance solution for ANY hydraulic system keeps an organization’s most valuable assets earning. Reliability as a Service is a hardware-enabled SaaS business model. Fluid Power AI provides out of the box, plug-n-play, real-time full system […]
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GoShare
We use technology to improve last-mile delivery and moving experiences for our customers. Our mission is to organize the world’s trucks to make them more accessible and useful. Our vision is to create the largest network of trucks in the world. More than 90,000 customers and 12,000 Delivery Professionals trust GoShare to deliver. 2019, 2020, […]
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HAI Solutions
HAI Solutions has developed a unique portfolio of medical devices addressing the growing plague of contamination within the operating room, emergency room and intensive care units. We are focused on launching both the MDD-Multiport Delivery Device and IVS-Intravenous Sterilizer. While these products are two separate devices, they are complimentary and tackle the arduous clinical workflows […]
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Hillhurst Biopharmaceuticals
Hillhurst Biopharmaceuticals, Inc. (“Hillhurst”), a clinical-stage biopharmaceutical company focused on developing oral therapies enabling the therapeutic use of low dose carbon monoxide (CO).
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Intrepid Automation
Intrepid Automation develops custom industrial 3D print systems to produce plastic, elastomeric, and cast metal parts.
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Ivy Energy
Ivy Energy is opening up the most cost-effective deployment model for residential solar by fixing the split incentive issue for MDUs and more.
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La Jolla NanoMedical
La Jolla NanoMedical is a platform product for non surgical treatment of skin cancer and certain other cancers.
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MediPrint Ophthalmics
MediPrint Ophthalmics (FKA Leo Lens Pharma) is an emerging San Diego-based clinical stage eye care pharmaceutical company focused on enhancing vision for life by developing and commercializing a proprietary ocular drug delivery portfolio. There are over 40 million soft contact lens wearers in the United States alone and most of them will develop some eye […]
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Meetlete
Meetlete’s mission is to create personal connections between fans and athletes. Our app gives fans the ability to experiences a one on one meet and greet with their favorite athletes.
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MuReva Phototherapy
MuReva Phototherapy has developed a novel device using photomodulation to treat oral mucositis, a very painful side effect of radiation therapy in cancer patients
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OmniSync
OmniSync is a VC and US Air Force-backed, single sign-on software to find and fund innovation. We use AL/NLP-powered context-matching algorithms to create non-obvious connections between public/private innovators, scouts, and funders. Our flagship product, TurboSBIR helps startups connect with $4B in Federal innovation funds.
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OrPro Therapeutics
OrPro Therapeutics, Inc. (San Diego, CA) is developing a therapeutic platform based on thioredoxin, a human protein disulfide-reducing enzyme with unique mucus-normalizing, anti-inflammatory and anti-infective properties.
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PatientPartner
PatientPartner is creating the home for healthcare. We are a platform that provides access to information and support by connecting patients to a community of top-tier physicians and other patients going through similar health concerns, surgeries, or treatments.
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ProciseDx
ProciseDx provides point-of-care testing that delivers precise, high-quality results—empowering physicians and patients
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Radicle Science
Radicle Science reimagines the traditional pharmaceutical and academic research model to deliver rigorous health outcome data at a fraction of the time and cost. Our virtual, direct-to-consumer clinical trials offer the first ever path to natural product validation.
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Shadowbox
Shadowbox is a ground-breaking, patented, secure, no-code SAAS integration platform that connects web applications without the need for APIs. Our first product was launched in late 2018 targeting interoperability in healthcare, connecting Electronic Health Records (“EHRs”) with Ancillary Healthcare Service Systems (i.e., Diagnostic Labs, Treatment Centers, Durable Medical Equipment, Hospice Care, and so on).
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Styx Biotechnologies
At Styx, we are reprogramming immune cells to generate more robust and enduring immune responses. Our pioneering approach has remarkably improved the effectiveness of existing, fragile vaccines, and developing novel vaccine-based therapies against deadly diseases like COVID-19, pancreatic cancer, among others.
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Tag-N-Trac
Our CMaaS (Continuous Monitoring as a Service) Platform combined with our discreet Smart Sense™label technology provides the fabric for thorough supply chain visibility and real-time analytics. Our solution uniquely combines the initial process of serialization/aggregation of inventories, condition monitoring, and real-time alerts to keep track of product integrity during the chain of custody.
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The Good Face Project
The Good Face Project is an AI-Powered SaaS platform for R&D and Innovation in the Cosmetics and Personal Care Industry. We have created the LARGEST science-backed and AI-powered cosmetic ingredients ontology, with over 100,000 individual cosmetic ingredients graded across 15 dimensions of safety and efficacy.
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Trabus Technologies
TRABUS provides professional support services to the U.S. government and specializes in the development of technical solutions across five major portfolios: Wireless Technologies, Artificial Intelligence & Data Science, Maritime Transportation, Environmental Informatics, and Cybersecurity.
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Trestle Biotherapeutics
Trestle Biotherapeutics is a pre-clinical stage company developing bioengineered therapies for patients living with end stage renal disease. Once implanted, these bioengineered stem cell-derived tissues will get patients off dialysis, delay their need for transplantation, and one day become replacement organs.
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Verity Packaging
Verity offers truly sustainable packaging solutions to brands and businesses committed to combating the plastic crisis. We are on a mission to raise the standards in both packaging options and services to our clients.
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Vizer
Vizer is a fitness app that incorporates user rewards and social impact through meal donation. In 2020, they were awarded $500K from Alliance Healthcare Foundation. In 2020, they graduated the Connect Springboard program.
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XILO
XILO helps insurance agencies compete against rising digital competition with an easy to use, fully customizable software platform they can use to engage with their customers, provide instant insurance quotes and automate sales workflows. As part of the next generation of agency technology, XILO is aiming to disrupt old muti-billion dollar incumbents who control the […]
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Yur
The #1 fitness tracker for AR / VR / Gaming and #1 health and wellness bot for Discord. Community is the modern-day moat for companies. YUR helps champion online communities in an engaging way by blending IRL & URL activities.
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